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A Multicenter Randomized Placebo-Controlled Clinical Trial of Pramipexole for Tourette's Syndrome

Identifieur interne : 001234 ( Main/Exploration ); précédent : 001233; suivant : 001235

A Multicenter Randomized Placebo-Controlled Clinical Trial of Pramipexole for Tourette's Syndrome

Auteurs : Roger Kurlan [États-Unis] ; Giovanna Crespi [États-Unis] ; Barbara Coffey [États-Unis] ; Kirsten Mueller-Vahl [Allemagne] ; Stephen Koval [États-Unis] ; Glen Wunderlich [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0248756

Descripteurs français

Pascal (Inist)
- Syndrome de Gilles de la Tourette, Tic, Pathologie du système nerveux, Etude multicentrique, Placebo, Essai clinique, Pramipexole, Stimulant dopaminergique, Traitement.

English descriptors

KwdEn :
- Clinical trial, Dopamine agonist, Gilles de la Tourette syndrome, Multicenter study, Nervous system diseases, Placebo, Pramipexole, Tic, Treatment.

Abstract

Background: Dopamine agonists could theoretically normalize the suspected central dopamine hypersensitivity in Tourette's syndrome. Methods: There was a multicenter randomized, placebo-controlled, double-blind clinical trial of pramipexole given for 6 weeks in 63 children and adolescents with Tourette's syndrome. Results: There were no significant differences in the adjusted mean change in the Total Tic Score of the Yale Global Tic Severity Scale for patients treated with pramipexole (-7.16) and placebo (-7.17). There were no significant treatment effects on change from baseline in the Global Severity score of the Yale Scale and parent- and investigator-scored Clinical Global Impression of Improvement. In patients with attention deficit hyperactivity disorder, there was improvement in DuPaul ADHD scale scores for patients receiving pramipexole compared with placebo. Conclusions: There was no evidence that pramipexole has efficacy in suppressing tics. Pramipexole may decrease symptoms of associated attention deficit hyperactivity disorder. ©2012 Movement Disorder Society.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Dopamine agonists could theoretically normalize the suspected central dopamine hypersensitivity in Tourette's syndrome. Methods: There was a multicenter randomized, placebo-controlled, double-blind clinical trial of pramipexole given for 6 weeks in 63 children and adolescents with Tourette's syndrome. Results: There were no significant differences in the adjusted mean change in the Total Tic Score of the Yale Global Tic Severity Scale for patients treated with pramipexole (-7.16) and placebo (-7.17). There were no significant treatment effects on change from baseline in the Global Severity score of the Yale Scale and parent- and investigator-scored Clinical Global Impression of Improvement. In patients with attention deficit hyperactivity disorder, there was improvement in DuPaul ADHD scale scores for patients receiving pramipexole compared with placebo. Conclusions: There was no evidence that pramipexole has efficacy in suppressing tics. Pramipexole may decrease symptoms of associated attention deficit hyperactivity disorder. ©2012 Movement Disorder Society.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Multicenter Randomized Placebo-Controlled Clinical Trial of Pramipexole for Tourette's Syndrome

A Multicenter Randomized Placebo-Controlled Clinical Trial of Pramipexole for Tourette's Syndrome

Source :

Descripteurs français

English descriptors

Abstract

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